Journal: Immunity & Ageing : I & A
Article Title: Qifuyin against CCL11-Induced cognitive impairment by inhibiting microglial senescence via CCR3 signaling
doi: 10.1186/s12979-025-00528-6
Figure Lengend Snippet: Qifuyin reduce senescence induced by CCL11 in CCR3-OE HMC3 cell. A - R : Typical representative figures of cell cycle detection in each group by flow cytometry. A . Con: HMC3; B . Sham: HMC3-Sham; C . OE: HMC3 CCR3-OE; D . OE + CCL11:CCL11; E . SB: SB297006; F . C-DISS: 3’,6-Disinapoylsucrose; G . C-G-Rg1: Ginsenoside Rg1; H . C-TEN: Tenuifolin; I . C-18β-GA: 18β-Glycyrrhetinic acid; J . C-LQ: Liquiritin; K . DISS: 3’,6-Disinapoylsucrose; L . G-Rg1: Ginsenoside Rg1; M . TEN: Tenuifolin; N . 18β-GA: 18β-Glycyrrhetinic acid; O . LQ: Liquiritin; P . Effects of Qifuyin on G0/G1 phase of HMC3 CCR3-OE cells; Q . Effects of Qifuyin on G2/M phase of HMC3 CCR3-OE cells; R . Effects of Qifuyin on S. phase of HMC3 CCR3-OE cells. U - V . Expression of p16 in HMC3 CCR3-OE cells; P - Q : Expression of p21 in HMC3 CCR3-OE cells. Mean ± S.D., n = 3, *** P < 0.001 vs. Sham group, # P < 0.05, ## P < 0.01, ### P < 0.001 vs. CCR3-OE group, Student’s t-test; & P < 0.05, && P < 0.01, &&& P < 0.001 vs. CCR3-OE + CCL11 group, One-way ANOVA analysis by GraphPad Prism 8.0.1
Article Snippet: The Qifuyin dry extract powder was provided by Lunan Pharmaceutical Group Corporation.
Techniques: Flow Cytometry, Expressing